597 papers
This study identifies SLC33A1 as the primary transporter responsible for exporting oxidized glutathione (GSSG) from the endoplasmic reticulum, a critical mechanism for maintaining ER redox homeostasis and ensuring proper protein maturation.
The paper introduces the Advanced Mobile Laboratory (AML), a field-deployable platform that integrates high-end imaging, cell sorting, and cryo-preparation technologies to enable immediate, multiscale analysis of environmental microbial communities directly at the sampling site, thereby bridging the gap between field ecology and mechanistic cell biology.
This study demonstrates that the FDA-approved PPARγ agonist rosiglitazone effectively redirects fibro-adipogenic progenitors from forming ectopic bone to generating ectopic fat, thereby eliminating heterotopic ossification lesions in mouse models of both fibrodysplasia ossificans progressiva and trauma-induced heterotopic ossification.
This study reveals that in budding yeast, the nuclear pore basket is a stoichiometric structure built through the cooperative interaction of Mlp1 and its paralog Mlp2, where Mlp2 acts independently to recruit Pml39 and additional Mlp1 subunits, thereby refining the current model of basket architecture.
This paper presents a modular, open-source, and scalable end-to-end workflow that integrates existing and new tools to streamline the processing, registration, segmentation, and visualization of 3D Correlative Light and Electron Microscopy (CLEM) datasets, thereby lowering technical barriers and enhancing throughput for research facilities.
This study identifies a cGMP-PRKG1-VASH1 signaling axis activated by neprilysin inhibition that phosphorylates VASH1 to suppress microtubule detyrosination, thereby providing a mechanistic basis for the therapeutic benefits of LCZ696 in heart failure.
This study reveals that immune cell directional persistence in complex 3D environments is stabilized not by the abundance of protrusions, but by the temporal organization of protrusion dynamics coordinated by two spatially distinct myosin II architectures at the leading edge and rear.
This study reveals that blind mole-rats achieve exceptional cardiac resilience to extreme hypoxia through an evolutionarily tuned, ULK1-dependent mitophagy pathway that clears damaged mitochondria and prevents cell death during oxygen deprivation.
This study identifies Msc1 as a glucose starvation-responsive regulator that accumulates at the nucleus-vacuole junction to drive its functional maturation and facilitate associated stress-responsive transcriptional programs in yeast.
This study reveals that tunneling nanotubes (TNTs) preserve cytoskeleton tension and Lamin A/C integrity to reverse α-synuclein-induced senescence in astroglia by facilitating YAP-mediated mechanical signaling between cells with differential actin tension.
This study demonstrates that transferrin (TF) is upregulated in endometriosis and contributes to the disease's pathogenesis by promoting the proliferation and migration of endometrial stromal cells while inhibiting their apoptosis, likely through the modulation of ferroptosis-related pathways.
This study demonstrates that nanosecond laser-driven proton FLASH radiotherapy selectively spares normal tissue by preserving mitochondrial homeostasis and preventing ferroptosis, while maintaining full tumor-killing efficacy.
This study demonstrates that aberrant activation of the AURKA/HDAC6 axis drives primary cilia shortening and fibroblast activation in Systemic Sclerosis, identifying AURKA as a promising therapeutic target to reverse the fibrotic phenotype.
This study demonstrates that the extracellular matrix gene *mec-9*, expressed in companion neurons rather than ciliated neurons, non-autonomously regulates *C. elegans* sensory cilia function, protein localization, microtubule structure, and extracellular vesicle shedding, thereby providing a model to investigate the link between cilia and the extracellular matrix in ciliopathies.
This study reveals that the sugar-derived metabolite UDP-GlcNAc regulates intestinal stem cell function by modulating O-GlcNAcylation, which in turn controls PPAR signaling to govern metabolic programming and stem cell behavior in response to dietary cues.
This study elucidates that PolDIP2 undergoes redox-dependent disulfide-linked dimerization via Cys143 within mitochondria, while a conserved C-terminal ApaG-domain motif is essential for its interaction with the monomeric form of PolDIP2 and the binding partner CHCHD2.
This study identifies a previously unrecognized intracellular metabolic axis involving CHPT1 and an enzymatically active pool of LCAT that selectively channels diacylglycerol into polyunsaturated cholesteryl esters to drive ferroptosis, revealing that subcellular lipid routing rather than bulk lipid abundance determines ferroptotic vulnerability and offering therapeutic potential for cancer and metabolic liver disease.
This study demonstrates that the lncRNA NORM is essential for proper chromosome segregation and cell cycle progression by mediating the Plk1-Bub1 interaction and stabilizing CDK1 through its association with Nsun2.
Maternal obesity programs intestinal stem cells in offspring to exhibit enhanced proliferation, self-renewal, and tumor susceptibility through a persistent immune-epithelial axis driven by IL-17A and PPAR signaling.
This study demonstrates that UV-induced stress granule formation is highly cell type-specific and distinct from canonical oxidative stress-driven granules, as evidenced by differential responses across cell lines and the failure of keratin overexpression or antioxidant treatment to inhibit UV-triggered granules.