361 papers
Cell biology is the study of life at its most fundamental unit: the cell. This field explores how these microscopic building blocks function, communicate, and replicate to sustain living organisms, from the simplest bacteria to complex human tissues. By understanding the machinery inside a cell, scientists unlock secrets about growth, disease, and the very nature of existence itself.
At Gist.Science, we track every new preprint uploaded to bioRxiv within this dynamic category. Our team processes each submission to provide both accessible plain-language explanations and detailed technical summaries, ensuring you can grasp complex discoveries without getting lost in dense jargon. Below are the latest papers in cell biology, offering a fresh look at the inner workings of life as they are shared with the world.
This study employs a genome-wide strategy to identify TXNDC15 as a novel, catalysis-independent essential factor in MARCHF6-mediated ERAD that regulates substrate exit from the ER and maintains lipid homeostasis.
This study establishes that airway epithelial homeostasis and stress adaptation in *Drosophila* are governed by a "Goldilocks principle" of JAK/STAT signaling, where balanced activity is essential for cell survival and integrity, while sustained overactivation drives pathological remodeling that is conserved across species and reversible via pharmacological inhibition.
This study demonstrates that integrating genetic code expansion with rational site selection allows for the minimally disruptive incorporation of the fluorescent noncanonical amino acid Anap into G3BP1 and TDP-43, enabling highly accurate visualization of their stress-induced dynamics and pathobiology in live cells and neurons without compromising protein function.
This study identifies small-molecule modulators that inhibit AHR, DOT1L, or GSK3 to dramatically enhance the efficiency and cytotoxic function of stroma-free, hiPSC-derived T cells, thereby establishing a robust strategy for scalable universal and autologous T cell therapies.
This study demonstrates that supplementing bull semen extenders with a low concentration (1%) of sustainably obtained blueberry extract significantly improves the post-thawing motility and quality of cryopreserved spermatozoa, offering a sustainable approach to enhancing reproductive outcomes in artificial insemination.
This study validates SERPINB2 as a robust, cross-platform chondrogenic biomarker and reveals a coordinated activation of the SERPIN network during cartilage lineage commitment, highlighting its potential role in regulating the chondro-osteogenic decision and its utility for osteoarthritis monitoring.
This study identifies Rab12 as a novel negative regulator of mitophagy and mitochondrial homeostasis, demonstrating that its depletion enhances the clearance of damaged mitochondria and links vesicular trafficking machinery to mitochondrial quality control with potential implications for neurodegenerative diseases.
This study identifies 17 proteins localizing to the complex feeding and flagellar apparatus of the marine heterotrophic flagellate *Diplonema papillatum*, including novel components like Mad2 and MBP65, thereby establishing a molecular foundation for understanding nutrient acquisition mechanisms in this abundant group of plankton.
This study reveals that SMN deficiency in Spinal Muscular Atrophy drives extensive, tissue-specific proteomic remodeling across multiple organs, with partial SMN restoration via antisense oligonucleotides only incompletely reversing these molecular alterations, particularly in metabolic and mitochondrial pathways.
This study demonstrates that inducible deletion of endothelial KLF4 in mice recapitulates the key clinical features of preeclampsia, including gestational hypertension and fetal growth restriction, thereby providing a novel model that links upstream cardiovascular risk factors to the disease's underlying mechanisms.